KEY ARTICLES
JournalDoc is proud to work with a team of experts who understand the challenges faced by Healthcare Professionals and pleased to offer a weekly article of interest representing trends and new information affecting the study and practice of medicine.
What’s Interesting about this article?
- The MIND diet is a hybrid of the Mediterranean and DASH diets with some modifications to include foods thought to reduce the risk of Alzheimer’s disease.
- This was a 3-year two site study involving older adults without cognitive impairment but with a family history of dementia.
- There was no significant difference in cognition or MRI outcomes in the MIND group and the control group at three years.
JournalDoc Comments:
- 94% of the trial participants completed the study, which indicates an exceptionally high level of adherence.
- It would be wonderful to have a dietary option for prevention of cognitive decline or Alzheimer’s, but dietary studies are difficult to complete because of lack of adherence or reliable food diaries. The MIND diet represents the best attempt to date, combining the proven benefits of both the Mediterranean and DASH diets.
Annals of Internal Medicine, September 2023
Study Design: Pooled Analysis of 5 Randomized Controlled Trials with Two Years of Individual Patient Data
What’s Interesting about this article?
- Weight Gain and Hypertension are well known adverse events of treatment with high dose glucocorticoids.
- This study provides solid evidence that low dose steroids over two years resulted in small increase in weight (one kg.) and no increase in blood pressure.
JournalDoc Comments:
- As mentioned in an accompanying AIM editorial, the “pendulum swings back” on the risks of low dose steroids in treating rheumatoid arthritis on a chronic basis.
- Previous observational studies appear to have overstated the impact on weight and blood pressure.
- Steroids are effective and low-cost drugs, and these findings may decrease patient and physician concerns over adverse effects in R.A. and potentially other chronic diseases.
Disclaimer: Article of the Week selections by JournalDoc physicians are independent, unbiased and have no commercial conflict of interest. JournalDoc does not support or endorse the findings or opinions expressed in the article. Findings in the article may need to be supported by further research and/or the consensus of experts.
Clinical Decisions Commentary
New England Journal of Medicine, August 17, 2023
Clinical Vignette followed by Pro and Con Expert Commentary
What’s Interesting about this article?
- The clinical case vignette involved a healthy 13-year-old boy with a normal physical exam and no history of concussions or heart problems. The father played football and enjoyed the camaraderie and competition but wonders if it is safe for his son to participate.
- Recent news reports on high-profile cases of chronic traumatic encephalopathy following repeated football concussions has both parents and physicians concerned about the dangers of this sport in high school students.
- The argument for participation states that there are multiple benefits of regular exercise and participation is sports, and that high-quality studies have found no association between participation in collision sports such as football and adverse changes in cognition or depression.
- The argument against participation states that there is no accepted evidence of the risk of CTE in a 13-year-old playing football, but the risk is not zero. A decision to play involves a discussion of risk benefit trade-offs and risk tolerance with family and youth.
JournalDoc Comments:
- Evaluation of risk should involve size and weight of boy, the position that he wants to play and head-to-head collision probability, and size and weight of competitors who will be playing opposite his position.
- If parents and boy have low risk tolerance and other non-contact sport options are available (tennis, swimming), it is probably best not to play football.
- If family and youth are willing to accept some degree of risk and post-concussion protocols are in place for the team, may be reasonable for youth to play and re-evaluate each year based on individual experience.
Disclaimer: Article of the Week selections by JournalDoc physicians are independent, unbiased and have no commercial conflict of interest. JournalDoc does not support or endorse the findings or opinions expressed in the article. Findings in the article may need to be supported by further research and/or the consensus of experts.
“The TRAILBLAZER-ALZ 2 Randomized Clinical Trial”
Journal of the American Medical Association (JAMA), July 17, 2023
Study Design and Number of Patients: RCT with 1736 participants in 277 medical centers in 8 countries; 18-month phase 3 trial
What’s Interesting about this article?
- Deposition of beta amyloid in the brain is an early event in Alzheimer disease, leading to neurofibrillary tangles and plaque composed of tau protein.
- Donanemab is a monoclonal antibody directed at amyloid and tau complexes.
- In this study, Donanemab significantly slowed clinical progression in those with early symptomatic Alzheimer disease at 76 weeks.
JournalDoc Comments:
- As mentioned in an accompanying JAMA editorial, this drug may “usher in a new era in Alzheimer therapy”.
- Removal of amyloid plaques may lessen the worsening of the disease, but is not a “cure”; so the modest clinical benefits must be balanced against adverse effects and the cost of the drug. Are amyloid and tau the cause of the disease, or just the result of damage to neurons?
Disclaimer: Article of the Week selections by JournalDoc physicians are independent, unbiased and have no commercial conflict of interest. JournalDoc does not support or endorse the findings or opinions expressed in the article. Findings in the article may need to be supported by further research and/or the consensus of experts.
Annals of Internal Medicine, June 27, 2023
Study Design and Number of Patients: Randomized Controlled Trial with 90 Adults with Obesity
What’s Interesting about this article?
- Time Restricted Eating has become a popular weight loss strategy because it is easier to do than counting calories.
- Whether time restricted eating without counting calories is effective has not been studied, so researchers randomly assigned participants to one of three groups – eight hours of eating per day (noon to 8 PM); calorie counting and a control group.
- Both time restricted eating and calorie counting resulted in an average weight loss of approximately 5 kg more than the control group over 12 months
JournalDoc Comments:
- This was a relatively small study with only 77 persons completing the study. However, the group was racially diverse, so findings are not confined to one race.
- Obesity is a major health issue with multiple associated comorbidities, so helpful to know that one can select whichever approach is easier for them to adhere to and lose 10-12 pounds over a 12-month period.
Disclaimer: Article of the Week selections by JournalDoc physicians are independent, unbiased and have no commercial conflict of interest. JournalDoc does not support or endorse the findings or opinions expressed in the article. Findings in the article may need to be supported by further research and/or the consensus of experts.