JAMA Original Investigation
Journal of the American Medical Association, January 2, 2024
Data from the SURMOUNT-4 Randomized Clinical Trial, a phase 3 open label withdrawal trial with 670 participants at 70 sites in 4 countries. Participants received once weekly subcutaneous injections of Tirzepatide for 36 weeks and then half were randomized to continue receiving drug or placebo for 52 weeks.
What’s Interesting about this article?
- Tirzepatide is a single molecule that combines glucose -dependent insulintropic polypeptide (GIP) and GLP-1 receptor agonism resulting in synergistic effects on appetite, food intake and metabolism.
- Tirzepatide was recently approved in the U.S. by the FDA, marketed as ZepboundTM.
- Withdrawing Tirzepatide resulted in substantial regain of lost weight, whereas continued treatment maintained and augmented weight reduction.
- These findings are consistent with other studies that found that patients must remain on the new weight loss drugs or substantial weight gain occurs.
- The requirement for long term use of Tirzepatide is worrisome because of loss of muscle and GI adverse effects reported with this class of drugs.
- Until the need for maintenance therapy is solved, the new weight loss drugs should only be prescribed for patients with obesity and either/or diabetes or cardiovascular disorders.
Disclaimer: Article of the Week selections by JournalDoc physicians are independent, unbiased and have no commercial conflict of interest. JournalDoc does not support or endorse the findings or opinions expressed in the article. Findings in the article may need to be supported by further research and/or the consensus of experts.