NEJM Original Article

The New England Journal of Medicine, February 9, 2024

Data from a multicenter, randomized, dose-finding trial of 255 patients with moderate-to-severe plaque psoriasis. Patients were randomly assigned to receive treatment at varying dosages with a novel orally administered interleukin-23-receptor antagonist peptide that selectively blocks interleukin-23 signaling and downstream cytokine production or a placebo for 16 weeks.

What’s Interesting about this article?

  • The use of monoclonal antibodies has changed the treatment of several immune-mediated inflammatory diseases, including psoriasis.
  • However, monoclonal antibodies are large proteins, which must be administered by injection.
  • The treatment of patients with this new orally administered drug showed greater efficacy than placebo.

JournalDoc Comments:

  • Development of an effective psoriasis drug that can be taken by mouth is a great benefit for patients.
  • In an accompanying editorial by Joel M. Gelfand, M.D., the doctor points out that advances in bioengineering have made it possible to administer large complex proteins by mouth, with semiglutide being a notable example.
  • This study focused on changes in the skin. It is not known what effect this drug will have on other organs or disorders affected by psoriasis, such as arthritis.


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